Skrining Fungsi Hati melalui Pemeriksaan Enzim Transaminase pada Masyarakat Dewasa di Kelurahan Jelambar

Authors

  • Alexander Halim Santoso Fakultas Kedokteran Universitas Tarumanagara, Jakarta
  • Bryan Anna Wijaya Fakultas Kedokteran, Universitas Tarumanagara, Jakarta, Indonesia
  • Anak Agung Ngurah Putrayoga Amertha Fakultas Kedokteran, Universitas Tarumanagara, Jakarta, Indonesia
  • Muhammad Rifat Umar Alwini Fakultas Kedokteran, Universitas Tarumanagara, Jakarta, Indonesia

DOI:

https://doi.org/10.69930/scitec.v3i1.629

Keywords:

Deteksi Dini; Enzim Transaminase; Fungsi Hati; Hepatik; Skrining

Abstract

Penyakit hati kronik merupakan salah satu penyebab utama morbiditas dan mortalitas di Indonesia, dengan sirosis hepatik sebagai tahap akhir yang sering terlambat terdeteksi. Rendahnya akses terhadap pemeriksaan laboratorium dan kurangnya kesadaran masyarakat terhadap faktor risiko menjadikan deteksi dini masih terbatas. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk melakukan skrining fungsi hati melalui pemeriksaan enzim transaminase pada masyarakat dewasa di Kelurahan Jelambar, Jakarta Barat, serta meningkatkan literasi kesehatan hepatik. Metode pelaksanaan menggunakan pendekatan promotif–preventif berbasis komunitas melalui edukasi kesehatan dan pemeriksaan kadar SGOT dan SGPT dengan analisis spektrofotometri. Sebanyak 46 partisipan berusia 20–63 tahun berpartisipasi secara sukarela. Hasil menunjukkan rerata kadar SGOT 26,46 ± 7,69 U/L dan SGPT 25,11 ± 6,3 U/L, dengan sebagian besar peserta memiliki nilai dalam batas normal, meskipun 17,4% menunjukkan peningkatan SGOT dan 2,2% peningkatan SGPT. Hasil ini mengindikasikan adanya sebagian kecil individu dengan potensi gangguan fungsi hati subklinis. Pelaksanaan skrining di tingkat komunitas terbukti efektif dan mudah diterapkan sebagai upaya deteksi dini sekaligus sarana edukatif untuk meningkatkan kesadaran masyarakat terhadap pentingnya menjaga kesehatan hati. Kegiatan ini diharapkan dapat menjadi model replikasi program promotif–preventif dalam pengendalian penyakit hati kronik di tingkat layanan primer.

Downloads

Download data is not yet available.

References

Al-Dayyat, H. M., Rayyan, Y. M., & Tayyem, R. F. (2018). Non-alcoholic fatty liver disease and associated dietary and lifestyle risk factors. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(4), 569–575. https://doi.org/10.1016/j.dsx.2018.03.016

Cacciola, I., Scoglio, R., Alibrandi, A., Squadrito, G., & Raimondo, G. (2017). Evaluation of liver enzyme levels and identification of asymptomatic liver disease patients in primary care. Internal and Emergency Medicine, 12(2), 181–186. https://doi.org/10.1007/s11739-016-1535-2

Cho, J.-Y., Jeong, J. Y., & Sohn, W. (2020). Risk of metabolic syndrome in participants within the normal range of alanine aminotransferase: A population-based nationwide study. PLOS ONE, 15(4), e0231485. https://doi.org/10.1371/journal.pone.0231485

Duo, H., You, J., Du, S., Yu, M., Wu, S., Yue, P., Cui, X., Huang, Y., Luo, J., Pan, H., & Ye, Q. (2025). Liver cirrhosis in 2021: Global Burden of Disease study. PLOS One, 20(7), e0328493. https://doi.org/10.1371/journal.pone.0328493

El-Kassas, M., Cabezas, J., Coz, P. I., Zheng, M.-H., Arab, J. P., & Awad, A. (2022). Nonalcoholic Fatty Liver Disease: Current Global Burden. Seminars in Liver Disease, 42(03), 401–412. https://doi.org/10.1055/a-1862-9088

Feby Cindi Lorenza, Ummi Maimunah, Puspa Wardhani, & Wiwin Retnowati. (2024). Characteristics of liver cirrhosis patients: A literature review. World Journal of Advanced Research and Reviews, 21(1), 942–948. https://doi.org/10.30574/wjarr.2024.21.1.0110

Frankowski, R., Kobierecki, M., Wittczak, A., Różycka-Kosmalska, M., Pietras, T., Sipowicz, K., & Kosmalski, M. (2023). Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation. International Journal of Molecular Sciences, 24(11), 9677. https://doi.org/10.3390/ijms24119677

Gamis, J., Mamesah, Y. P. M., & Timban, J. F. J. (2025). Gambaran Ultrasonografi Hati pada Pasien Non-Alcoholic Fatty Liver Disease dengan Hipertensi. Medical Scope Journal, 8(1), 1–6. https://doi.org/10.35790/msj.v8i1.59939

Giagulli, V. A., Castellana, M., Pelusi, C., & Triggiani, V. (2019). Androgens, Body Composition, and Their Metabolism Based on Sex (pp. 18–32). https://doi.org/10.1159/000494900

Husain, F. S., Tey, S. L., Huynh, D. T. T., Oliver, J., Baggs, G., How, C. H., Chow, W. L., Cheong, M., Aw, T. C., Chew, S. T. H., & Tan, N. C. (2025). Aging and liver health: liver chemistries and associated factors in community-dwelling older adults. BMC Geriatrics, 25(1), 658. https://doi.org/10.1186/s12877-025-06329-2

Josol, V. J. D., Salvador, P. B. U., Cruz, L. L. A., Ornos, E. D. B., & Tantengco, O. A. G. (2024). Trends of nonalcoholic fatty liver research in Southeast Asia from 2004 to 2022: A bibliometric analysis. Obesity Medicine, 45, 100527. https://doi.org/10.1016/j.obmed.2023.100527

Kwak, H. C., Kim, H. C., Oh, S. J., & Kim, S. K. (2015). Effects of age increase on hepatic expression and activity of cytochrome P450 in male C57BL/6 mice. Archives of Pharmacal Research, 38(5), 857–864. https://doi.org/10.1007/s12272-014-0452-z

Lala, V., Zubair, M., & Minter, D. (2023). Liver function tests. StatPearls.

MacLean, H. E., & Handelsman, D. J. (2009). Unraveling Androgen Action in Muscle: Genetic Tools Probing Cellular Mechanisms. Endocrinology, 150(8), 3437–3439. https://doi.org/10.1210/en.2009-0438

Matz-Soja, M., Berg, T., & Kietzmann, T. (2025). Sex-related variations in liver homeostasis and disease: From zonation dynamics to clinical implications. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2025.08.007

No, V., Faktor, A., & Sirosis, T. (2025). Analisis faktor terjadinya sirosis hepatis di rsud ibnu sina gresik. 2(1), 45–51.

Salama, R., Emara, M., & Eldeep, A. (2019). Relationship between Elevated Liver enzymes and Metabolic syndrome among Egyptian adults. Afro-Egyptian Journal of Infectious and Endemic Diseases, 9(3), 199–206. https://doi.org/10.21608/aeji.2019.12382.1021

Tajiri, K. (2013). Liver physiology and liver diseases in the elderly. World Journal of Gastroenterology, 19(46), 8459. https://doi.org/10.3748/wjg.v19.i46.8459

Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022). Understanding the cellular interactome of non-alcoholic fatty liver disease. JHEP Reports, 4(8), 100524. https://doi.org/10.1016/j.jhepr.2022.100524

Xu, S.-F., Hu, A.-L., Xie, L., Liu, J.-J., Wu, Q., & Liu, J. (2019). Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats. PeerJ, 7, e7429. https://doi.org/10.7717/peerj.7429

Yang, H., Ou, F., Chang, Q., Jiang, J., Liu, Y., Ji, C., Chen, L., Xia, Y., & Zhao, Y. (2024). Physical frailty, genetic predisposition, and the risks of severe non‐alcoholic fatty liver disease and cirrhosis: a cohort study. Journal of Cachexia, Sarcopenia and Muscle, 15(4), 1491–1500. https://doi.org/10.1002/jcsm.13506

Zhang, J.-W., Zhang, N., Lyu, Y., & Zhang, X.-F. (2025). Influence of Sex in the Development of Liver Diseases. Seminars in Liver Disease, 45(01), 015–032. https://doi.org/10.1055/a-2516-0261

Downloads

Published

2026-01-24

How to Cite

Santoso, A. H., Wijaya, B. A., Amertha, A. A. N. P., & Alwini, M. R. U. (2026). Skrining Fungsi Hati melalui Pemeriksaan Enzim Transaminase pada Masyarakat Dewasa di Kelurahan Jelambar. Science and Technology: Jurnal Pengabdian Masyarakat , 3(1), 44–53. https://doi.org/10.69930/scitec.v3i1.629

Most read articles by the same author(s)

1 2 > >> 

Similar Articles

<< < 1 2 3 

You may also start an advanced similarity search for this article.